High expression of long noncoding RNA AB073614 in colorectal cancer patients and its clinical significance

More and more studies have suggested that long non-coding RNAs (LncRNAs) are involved in different physiological or physiopathologic processes including the development of cancer. Previous studies have suggested long noncoding RNA AB073614 (lncRNA AB073614) is involved in ovarian cancer and glioma, but its role in colorectal cancer (CRC) is still unclear. A study was thus performed to examine the expression of lncRNA AB073614 in CRC patients and its clinical significance. A total of 51 CRC patients were included in the study. Expression of lncRNA AB073614 in tumor tissues and paired adjacent non-tumor tissues were detected by Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR). Logistic regression analysis was also performed. The relative expression of lncRNA AB073614 in the CRC tumor tissues was significantly higher when compared with the paired normal tissues (P < 0.0001). The expression of lncRNA AB073614 in the tumor tissues was obviously higher in CRC patients with high grade (P = 0.003), larger tumor size (> 5 cm) (P = 0.008), distant metastasis (P = 0.0007), or poor differentiation (P = 0.01). Multivariate logistic regression analysis suggested high expression of lncRNA AB073614 was independently associated with higher possibilities of high grade (OR = 26.08; P = 0.01), distant metastasis (OR = 91.14; P = 0.03) and poor differentiation (OR = 28.15; P = 0.006). The findings above suggest that lncRNA AB073614 may participate in the carcinogenesis and progression of CRC. More researches are needed to validate the role of lncRNA AB073614 in CRC, and to explore the underlying molecular mechanism.